Dr. Drs. Kusmardi, M.Sc.

NIP:
196503271990031001
Fakultas:
Fakultas Kedokteran
Organisasi:
Patologi Anatomik
Pendidikan:
S3

Profile

DR. Drs. Kusmardi, MSc:
Assoc. Professor (Lektor Kepala)

Dept. Patologi Anatomik FK UI, Jakarta

Home base:
Program Doktor Ilmu Biomedik FK UI

Bidang Riset :

Immunology, Pathology, Cancer Biology, Herbal Medicine, Biomedical Sciences, Oncology, Animal Model for Cancer Research, Biostatistic, and
Research Methodology

Penghargaan:

1. Peneliti Muda Indonesia Terbaik Bidang Kesehatan tahun 1996. Lembaga Ilmu Pengetahuan
Indonesia.
2. Finalis Peneliti Muda Indonesia Terbaik Bidang Kesehatan tahun 1998. Lembaga Ilmu Pengetahuan
Indonesia.
3. Peneliti Terbaik tahun 2000. Persatuan Onkologi Indonesia.
4. Satyalencana Karya Satya 10 tahun (2004). Presiden RI (Megawati Soekarnoputri)
5. Satyalencana Karya Satya 20 tahun (2012). Presiden RI (Susilo Bambang Yudhoyono)
6. Peneliti Potensial dengan H index >2. Dekan FK UI (2012)
7. Peneliti Potensial berdasarkan artikel di SCOPUS.Dekan FKUI (2012)
8. Beberapa penghargaan dari Departemen Patologi Anatomik sebagai Peneliti Terbaik di Departemen
Patologi Anatomik FKUI.
9. Penghargaan Penelitian Terbaik III FKUI tahun 1994. Dekan FKUI.

Reviewer Jurnal:

1. Majalah Patologi Indonesia (Terakreditasi) (Pemimpin Redaksi)
http://majalahpatologiindonesia.com/p/index.php/patologi/about/editorial...
2. Majalah Pratista Patologi (Pemimpin Redaksi)
http://majalahpratistapatologi.com/p/index.php/journal/Redaksi
3. International Journal of Medical and Clinical Research (Reviewer)
4. International Journal of Tropical Medicine and Public Health (Scientific Advisory Board)

Reviewer Program Studi Kedokteran:

1. Assessor of BAN PT/ LAM PT Kes
2. Ketua Tim Penjamin Mutu Akademik Program S3 Ilmu Kedokteran FKUI
3. Ketua Tim Penjamin Mutu Akademik Program S3 Ilmu Biomedik FKUI (2017-2019)
4. Reviewer Hibah Penelitian Kemenristekdikti
5. Reviewer Hibah Penelitian FK UI

Fellowships Reviewer:

Reviewer of LPDP

Buku:

1. LUNASIN PROTEIN PADA KEDELAI DAN HASIL RISET TERKAIT HAMBATAN PADA PERJALANAN KANKER
KOLON (UI PUBLISHING, ISBN : 9789794967753, 2019).
2. Hewan Model Kanker Kolorektal. (UI PUBLISHING, ISBN :ISBN : 9789794567425, 2018).
3. Mencit sebagai Model Riset Kanker Payudara Manusia. (Badan Penerbit Fakultas Kedokteran
UI. ISBN : 97897948688952015).
4. Berkawan dengan Biostatistik(UI Publishing, inpress)

Patent:
1. Lunasin Dari Kedelai Grobogan Berpotensi Mengurangi Pertumbuhan Kanker Payudara (P00201911511)
2. Lunasin dari kedelai penghambat proses epigenetik terjadinya kanker usus besar (P00201907009).
3. Lunasin dari kedelai grobogan penghambat karsinogenesis kolon (P00201906791)
4. Senyawa analog baru antimycin A3 sebagai penghambat pertumbuhan sel-sel kanker payudara dan metode pembuatannya (IDP000049259).
5. Pengembangan Model Kanker Endometrioid Pada Tikus (EC00201809564)

Product::

Kus-ω3r-di (Omega-3 untuk pencegahan radang dan kanker kolon, dari minyak ikan yang diperkaya)

Publications::

Kusmardi Kusmardi, Aryo Tedjo,A, Yurnadi Hanafi Midoen, And Michael Adrian. Photoelectrochemical Measurement Of Epstein-Barr Virus DNA In Peripheral Blood Serum Of Nasopharyngeal Carcinoma Patients. AIP Conference Proceedings 2193, 040009 (2019); Https://Doi.Org/10.1063/1.5139371

Retno Widyawati, Budiningsih Siregar, And Kusmardi Kusmardi. Decrease Expressions Of ARID1A In Non-Atypical, Atypical Endometriosis Cyst And Ovarian Clear Cell Carcinoma As A Biomarker Of Malignancy Transformations. AIP Conference Proceedings 2193, 040010 (2019) December, 2193, 040010 (2019).

Nurhuda, Rosalina Thuffi, Dwi Ari Pudjianto, R. Muharam, Ninik Mudjihartini, Andhea Debby Pradhita, And Kusmardi Kusmardi. High Progesterone Levels On The Day Of Hcg Administration In Controlled Ovarian Hyperstimulation Procedures Reduce The Expression Of Progesterone Receptors In The Endometrium Macaca Nemestrina AIP Conference Proceedings 2193, 040007 (2019); Https://Doi.Org/10.1063/1.5139369 December, 2193, 040007 (2019);

Ari Estuningtyas1 *, Santi Widiasari2 , Melva Louisa1 , Kusmardi. The Effect Of Mahkota Dewa (Phaleria Macrocarpa L.) Leaf Extract Encapsulated In Chitosan Nanoparticles On Inos And COX-2 Expression In Dextran Sodium Sulphate-Induced Colitis Mice Model. Journal Of International Dental And Medical Research. Http://Www.Jidmr.Com/Journal/Wp-Content/Uploads/2019/04/39-M18425-ED-2_AR_Ari-Estuningtyas-M.Pdf Volume ∙ 12 ∙ Number ∙ 1 ∙ 2019; 220-226, January

Sahar, N.; Mujihartini, N.; Pudjianto, D.A.; Pradhita, A.D.; Thuffi, R.; Kusmardi, K. Increased Progesterone on the Day of Administration of hCG in Controlled Ovarian Hyperstimulation Affects the Expression of HOXA10 in Primates’ Endometrial Receptivity.Biomedicines 2019, 7, 83. https://doi.org/10.3390/biomedicines7040083

Kusmardi Kusmardi , Inne Caroline , Puspita Eka Wuyung , Ria Kodariah , Salinah. The Effect of Higher Temperature on the Aggressiveness of the Mice Adenocarcinoma Mammae Cells. Journal of International Dental and Medical Research. J Int Dent Med Res 2019; 12(3): 935-940. http://www.jidmr.com/journal/wp-content/uploads/2019/10/16-D3_19270_Sali...

Ari Estuningtyas1 , Santi Widiasari , Melva Louisa , Kusmardi Kusmardi. The Effect of Mahkota Dewa (Phaleria Macrocarpa L.) Leaf Extract Encapsulated in Chitosan Nanoparticles on iNOS and COX-2 Expression in Dextran Sodium Sulphate-Induced Colitis Mice Model. Journal of International Dental and Medical ResearchVolume ∙ 12 ∙ Number ∙ 1 ∙ 2019; 220-226. http://www.jidmr.com/journal/wp-content/uploads/2019/04/39-M18425-ED-2_A...

Kusmardi, Kusmardi., Tumpu, N. A., & Estuningtyas, A. (2019). Phaleria Macrocarpa Leaf Extract-Chitosan Nanoparticles Supress Angiogenesis Induced By Dextran Sodium Sulfate In Mice Colon. International Journal of Applied Pharmaceutics, 11(6), 122-124. https://doi.org/10.22159/ijap.2019.v11s6.33574 https://innovareacademics.in/journals/index.php/ijap/article/view/33574

KUSMARDI, K., KARENINA, V., ESTUNINGTYAS, A., & TEDJO, A. (2019). INHIBITION OF COX-2 EXPRESSION BY LUNASIN-RICH SOYBEAN EXTRACT ON COLORECTAL CANCER. International Journal of Applied Pharmaceutics, 11(6), 116-121. https://doi.org/10.22159/ijap.2019.v11s6.33572 https://innovareacademics.in/journals/index.php/ijap/article/view/33572

KUSMARD, K., TARIGAN, T. R. S., ESTUNINGTYAS, A., & TEDJO, A. (2019). EFFECT OF LUNASIN-ENRICHED SOY EXTRACT ON HISTONE DEACETYLASE EXPRESSION IN DISTAL COLON EPITHELIAL CELLS FROM AOM/DSS-INDUCED MICE. International Journal of Applied Pharmaceutics, 11(6), 111-115. https://doi.org/10.22159/ijap.2019.v11s6.33541 https://innovareacademics.in/journals/index.php/ijap/article/view/33571

KUSMARDI1, KHIPUTRA, H., & SALINAH. (2019). THE EFFECT OF LUNASIN ON LIVER HISTOPATHOLOGY OF MICE INDUCED BY AZOXIMETHANE (AOM) AND DEXTRAN SODIUM SULPHATE (DSS). International Journal of Applied Pharmaceutics, 11(6), 84-87. https://doi.org/10.22159/ijap.2019.v11s6.33552 https://innovareacademics.in/journals/index.php/ijap/article/view/33552.

KUSMARDI, K., TAMARA, R., ESTUNINGTYAS, A., & TEDJO, A. (2019). EFFECT OF LUNASIN-RICH SOYBEAN EXTRACT UPON TNF-α EXPRESSION ON COLONIC EPITHELIAL CELLS OF MICE INDUCED BY AZOXYMETHANE/DEXTRAN SODIUM SULFATE. nternational Journal of Applied Pharmaceutics, 11(6), 12-16. https://doi.org/10.22159/ijap.2019.v11s6.33527 https://innovareacademics.in/journals/index.php/ijap/article/view/33527.

Kusmardi, Dean Adare, Ria Kodariah. The Effect of Omega-3-enriched Fish oil on the Inflammation of Mice Colon Induced by AOM and DSS: Study on COX-2. Research J. Pharm. and Tech. 2019; 12(11): 5465-5468. DOI: 10.5958/0974-360X.2019.00911.9 https://www.scimagojr.com/journalsearch.php?q=21100197160&tip=sid&clean=0.

Hartono Tjahjadi, Laurencia Leny Kurnianingrum and Kusmardi Kusmardi*: OVARIAN SERTOLI-LEYDIG CELL TUMOR: REPORT OF A RARE CASE. European Journal of Biomedical AND Pharmaceutical sciences...Volume: 6 Issue: 2 63-69 Year: 2019 https://www.ejbps.com/ejbps/archive_show/2019/Volume%206,%20February%20I....

ARI ESTUNINGTYAS1*, SANTI WIDIASARI2, KUSMARDI KUSMARDI. ACUTE TOXICITY OF CHITOSAN NANOPARTICLES CONTAINING MAHKOTA DEWA (PHALERIA MACROCARPA) LEAF EXTRACT AND ANTI-INFLAMMATORY EFFECTS IN A DEXTRAN SODIUM SULFATE-INDUCED MOUSE MODEL OF ULCERATIVE COLITIS. IJAB Vol 10, Special Issue 1, 2018.

Kusmardi Kusmardi1 , Nessa Nessa4 , Ari Estuningtyas2 , Aryo Tedjo3. The effect of lunasin from Indonesian soybean extract on histopatologic examination and cox-2 expression in dextran sodium sulfate-induced mice colon. Int J Physiol Pathophysiol Pharmacol 2018;10(6):154-162 www.ijppp.org /ISSN:1944-8171/IJPPP0086511.

Kusmardi, K., Estuningtyas, A. Shavera, D., Aryo, T., Priosoeryanto, B.P., Habiburrahman, M., Salinah. The effect of Mahkota Dewa (Phaleria Macrocarpa) (Scheff.) fruit pericarp extract on COX-2 and β-catenin expression in mice colon induced by dextran sodium sulfate. Pharmacologyonline
Volume 2, 30 August 2018, Pages 199-205.
https://remote-lib.ui.ac.id:2074/record/display.uri?eid=2-s2.0-850527572...

Ade Arsianti,,Fadilah Fadilah, Kusmardi Kusmardi, Gede Y. Sugiarta, Hiroki Tanimoto,
Kiyomi Kakiuchi. In Silico Study And Cytotoxicity Of The Synthesized Open-Chain Analogues Of Antimycin A3 Against Hep-2 Laryngeal Cancer Cells. Current Cancer Therapy Reviews, 2017, 13, 129-136. 2018.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755020/

Euginia Christa, Kusmardi. Effect of Lunasin Extract on Histopathology of Mice Induced with Azoxymethane and Dextran Sodium Sulfate: Focus on Small Intestine Changes. Advanced Science Letters, Volume 24, Number 8, August 2018, pp. 6117-6124(8)
http://www.ingentaconnect.com/content/asp/asl/2018/00000024/00000008/art.... 2018.

Maria Francisca1; Soewondo Pradana2; Dien Saphora2; Kusmardi, Kusmardi1; Kanoko Mpu1.
Epidermal Vascular Endothelial Growth Factor Improved Wound Healing of Patients with Diabetic Foot Ulcer. Advanced Science Letters, Volume 24, Number 8, August 2018, pp. 6136-6139(4)
http://www.ingentaconnect.com/content/asp/asl/2018/00000024/00000008/art.... 2018.

Salinah; Ekawuyung, Puspita; Wiweko Budi; Kodariah Ria; Kusmardi. Expression of p16INK4a in Endometrioid Cancer Rat Model. Advanced Science Letters, Volume 24, Number 9, September 2018, pp. 6584-6586(3)
http://www.ingentaconnect.com/content/asp/asl/2018/00000024/00000009/art.... 2018.

Kusmardi Kusmardi, Aryo Tedjo, Fadilah, Ade Arsianti , Rafika Indah Paramita. Identification By Docking Simulation And In Vivo Effect Of Essential Oil From Cinnamommum Burmannii As Antiobesity With Leptin Receptor In The Olfactory System Of Mice Balb C.Pharmacognosy Journal 2018.2018 , Bln: 09.https://phcogj.com/sites/default/files/PharmacognJ-10-5-875.pdf

Kusmardi, Kusmardi, Aryo Tedjo, Eka Wuyung Puspita, Fadilah Fadilah, Pontjo Priosoeryanto Bambang, And Wilzar Fachri. Pharmacognosy Journal, June 2018, Volume 10, Issue 4, P.808-813, (2018) Pharmacognj-10-808.In Silico, In Vitro And In Vivo Tests Of Ficus Deltoidea Jack Leaves Extract As Inhibitor For Beta-Catenin Expression In Colon Carcinogenesis Model.Pharmacognosy Journal.2018 , Bln: 07.http://www.phcogj.com/article/625.

Kusmardi Kusmardi, Arif Ramadhan Tamzir, Santi Widiasari, Ari Estuningtyas.Suppression Effect Of Mahkota Dewa (Phaleria Macrocarpa) Leaf Extract In Chitosan Nanoparticles On The Small Intestine Of Dextran Sulfate Sodium-Induced Mice: Focus On Mitosis And Hyperplasia.Asian Journal Of Pharmaceutical And Clinical Research. Vol 11, Juni.2018 , Bln: 06.https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/2....

Wachid Putranto, Imam Effendi, Kusmardi Kusmardi, Hamzah Shatri.Combination Effect Of Lisinopril And Diltiazem As Anti Fibrosis In Peritoneum Of Rats.Asian Journal Of Pharmaceutical And Clinical Research. Vol 11.2018 , Bln: 03.https://innovareacademics.in/journals/index.php/ajpcr/article/view/23152.

Kusmardi Kusmardi, Nessa Nessa, Ari Estuningtyas, Aryo Tedjo, Puspita Eka Wuyung.The Effect Of Lunasin From Soybean Extract On Inos And Β-Catenin Expression In Dextran Sodium Sulfate-Induced Mice Colon.Asian Journal Of Pharmaceutical And Clinical Research. Vol 10.2018 , Bln: 01.https://innovareacademics.in/journals/index.php/ajpcr/article/view/21811.

Kusmardi Kusmardi, Muhammad Farhan Maruli, Aryo Tedjo, Anindini Winda Amalia, Berna Elya.Suppression Of Colitis-Associated Colon Carcinogenesis In Mice By Lunasin In Grobogan And Commercial Soybean Meal Extract.Asian Journal Of Pharmaceutical And Clinical Research. Vol 10.2017 , Bln: 08.https://innovareacademics.in/journals/index.php/.../13708.

Kusmardi Kusmardi, Berna Elya, Tri Wahyuni, Rafika Indah Paramita.Combination Of Sambiloto (Andrographis Paniculata Nees) Extract And Spirulina (Arthrosphira Platensis Gomont) To Prevent Anemia In Mice Infected With Plasmodium Berghei Anka.Asian Journal Of Pharmaceutical And Clinical Research. Vol 10.2017 , Bln: 08.https://innovareacademics.in/journals/index.php/ajpcr/article/view/21231....

Erwina Muhadi, ES Rosstini, Kusmardi.Apoptotic Index To Improve Diagnostic Accuracy In Medullary Breast Carcinoma In Excision/Mastectomy And Core Biopsy Simulation.Asian Journal Of Pharmaceutical And Clinical Research. Vol 10.2017 , Bln: 08.https://www.pathologyjournal.rcpa.edu.au/article/S0031-3025(16)31174-6/fulltext.

Kusmardi Kusmardi, Dony Hermanto, Ari Estuningytas, Aryo Tedjo, Bambang P Priosoeryanto.The Potency Of Indonesia’s Pomegranate Peel Ethanol Extract (Punica Granatum Linn.) As Anti-Inflammatory Agent In Mice Colon Induced By Dextran Sodium Sulfate: Focus On COX-2 And Inos Expressions.Asian Journal Of Pharmaceutical And Clinical Research. Vol 10.2017 , Bln: 08.https://innovareacademics.in/journals/index.php/ajpcr/article/view/21390.

Kusmardi K; Estuningtyas, A ; Shavera D*; Tedjo Aryo, Priosoeryanto Bp.The Effect Of Mahkota Dewa (Phaleria Macrocarpa) (Scheff.) Fruit Pericarp Extract On Cox-2 And Β-Catenin Expression In Mice Colon Induced By Dextran Sodium Sulfate.Clinical Research. Vol 10.2017 , Bln: 08.https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/2....

Kusmardi Kusmardi, Ari Estuningtyasb, Dilla Shavera Aryo Tedjo, Bambang P Priyosoeryanto.The Effect Of Mahkota Dewa (Phaleria Macrocarpa) (Scheff.) Fruit Pericarp Extract On Inos In Mice Colon Intermittenly Induced By Dextran Sodium Sulfate.Asian Journal Of Pharmaceutical And Clinical Research. Vol 10.2017 , Bln: 08.https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/2....

Anindini Winda Amalia, Kusmardi, Berna Elya, Ade Arsianti.Inhibition Of Carcinogenesis By Seed And Soybean Meal Extract In Colon Of Mice: Apoptosis And Dysplasia.Asian Journal Of Pharmaceutical And Clinical Research. Vol 10, Issue 4, 2017.https://innovareacademics.in/journals/index.php/ajpcr/article/view/16276.

Wijiasih, Kusmardi,Berna Elya
The Effect Of Soybean And Soybean Meal Extract On COX-2 And Inos Expression In Colon Preneoplasia Of Mice Induced By Azoxymethane And Dextran Sodium Sulfate.International Journal Of Chemtech Research Vol.10 No.1 Pp 39-46, 2017.http://www.sphinxsai.com/2017/ch_vol10_no1/1/(39-46)V10N1CT.pdf

Astra Suryani Putri1, Kusmardi, Berna Elya.
Inhibitory Activity Of Indonesian Soybean In Comparison With Soybean Meal On Goblet Cell Count And Micro Vessel Density In Colitis-Associated Mouse Colon Carcinogenesis.International Journal Of Pharmtech Research, Vol.10, No.1, Pp 09-18, 2017.http://sphinxsai.com/2017/ph_vol10_no1/1/(09-18)V10N1PT.pdf

Fadilah, Ade Arsianti, Kusmardi, Aryo Tedjo.Molecular Docking Studies Of Opened-Chain Analogues Of Antimycin A Ascaspases Inhibitors Of Apoptosis In Colorectal Cancer 3. Asian Journal of Pharmaceautical and Clinical Research. 2016. 9(3): 350-2.https://innovareacademics.in/journals/index.php/ajpcr/article/view/11485.

Ade Arsianti, Fadilah, Kusmardi, Hiroki Tanimoto, Kiyomi Kakiuchi. Design, synthesis, and cytotoxicity evaluation of novel openǧchain analogues of antimycin a3 as potential antiǧcolorectal cancer agents. Asian Juornal of Pharmaceutical and Clinical Research. 2015; 8 (6): 1-5.http://www.eurekaselect.com/node/154162/article/in-silico-study-and-cyto....

Novianry V, Yulhasri, Kusmardi. Serum cell-free DNA concentration in Balb/C mice with azoxymethane-dextran sodium sulfate-induced colorectal cancer. Indonesian Medical Journal 2015; 24(1): 3-7.http://mji.ui.ac.id/journal/index.php/mji/article/view/730.

Handayani SI, Kusmardi, Tedjo A. The Immunomodulation of Mangiferin on the Proliferation and Interleukin-2 Receptors Expression of in Vitro Culture of T lymphocytes Derived from Mammary Tumor Bearing Mice. Journal of Applied Biotechnology 2015;2:11-19.http://www.macrothink.org/journal/index.php/jab/article/view/6423.

Kusmardi, Priosoeryanto BP, Harlina E, Cornain S. Inhibition Activities of Fish Oil in iNOs, COX-2, and betha-Catenin Expressions in Colorectal Preneoplasia of Mice Induced by Azoxymethane and Dextran Sodium Sulfate. Journal of Applied Biotechnology 2014;2:91-101.http://staff.ui.ac.id/system/files/users/kusmardi.ms/publication/isi_jab....

Kusmardi, Tedjo A, Louisa M, Fadilah, Amelia P. The Effect of Ethanol Extract of Tabat Barito (Ficus deltoide Jack.) leaves on the Colon Mucosa Morphological Changes of Azoxymethane (AOM) and Dextran Sodium Sulfate (DSS)-Induced Mice. The Second Korea-ASEAN Symposium on Indonesian Natural Products in The Utilizing The Rich Varieties of Natural Resources and High Technology for Health and Beauty. Central Library, Universitas Indonesia, 15-16 August, 2014.http://www.phcogj.com.

Kusmardi, Tedjo A, Fadilah, Arsianti A. Inhalation of Cinnamomum burmannii Bark and Leaves Essential Oils Enhances The Expression of Leptin Receptor of Mice Hypothalamic. The Second Korea-ASEAN Symposium on Indonesian Natural Products in The Utilizing The Rich Varieties of Natural Resources and High Technology for Health and Beauty. Central Library, Universitas Indonesia, 15-16 August, 2014.http://www.phcogj.com.

Arsianti A,Fadilah, Kusmardi, Tanimoto H, Morimoto T, Kakiuchi K. Design and Molecular Docking Study of Antimycin A3 Analogues as Inhibitors of Anti-Apoptotic Bcl-2 of Breast Cancer.Open Journal of Medicinal Chemistry, 2014, 4 Published Online September 2014 in SciRes. http://www.scirp.org/journal/ojmc

Kusmardi, Priosoeryanto BP, Harlina E, Cornain S. Aktivitas Minyak Ikan dalam Menghambat Preneoplasia Kolon Mencit yang Diinduksi Azoksimetan dan Dextran Sodium Sulfate. Jurnal Ilmu Kefarmasian Indonesia, Vol 12, No. 2, September 2014: 154-161.http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/download/....

Syamsudin, Kusmardi. Anticancer activity study of ethylacetate fraction of Indonesian Propolis. Journal of Pharmacy Research 2011,4(12),4408-4410. ISSN: 0974-6943. www.jpronline.info

Syamsudin, RM Dewi, Kusmardi. Immunomodulatory and In vivo Antiplasmodial Activities of Propolis Extracts American Journal of Pharmacology and Toxicology 4 (3):75-79, 2009 ISSN 1557-4962.http://thescipub.com/abstract/10.3844/ajptsp.2009.75.79

Syamsudin, Darmono, Kusmardi. The Effect of Garcinia parvifolia Miq (Active Fraction) on Phagocytosis by Peritoneal Macrophages During Plasmodium berghei Infection in Mice. Res J Immunol 1(1): 16-20, 2008, ISSN 1994-7909.https://scialert.net/abstract/?doi=rji.2008.16.20.